Robert Ekiert, PhD

    Associate Professor

    2012 PhD (Molecular and Cell Biology); University of Edinburgh
    2008 MSc by Research (Life Sciences); University of Edinburgh
    2007 MSc (Biotechnology; Medical Biotechnology); Jagiellonian University

    Contact

    Room: A026
    Phone: 12 664 65 90
    e-mail: robert.ekiert(at)uj.edu.pl

    Work experience

    2013-2015 Young doctors Intership "Society - Environment - Technology" Project of the Jagiellonian University Project co-financed by the European Union under the European Social Fund
    2008-2012 Wellcome Trust 4 year PhD Programme; Wellcome Trust Centre for Cell Biology, University of Edinburgh;
    2008 Institute of Immunology and Infection Research, University of Edinburgh
    2008 Wellcome Trust Centre for Cell Biology, University of Edinburgh
    2007 Centre for Integrative Physiology, University of Edinburgh
    2006-2007 MSc; Department of Medical Biotechnology, Jagiellonian University
    2006 Socrates/Erasmus Scholarship; Department of Cell and Molecular Biology, Uppsala University

    Publications:

    1. Lyst M.J., Ekiert R., Guy J., Selfridge J., Koerner M.V., Merusi C., De Sousa D., Bird A. (2018) Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2 Cell Reports 24, 2213-2220

    2. Borek A, Ekiert R., Osyczka A, (2018) Functional flexibility of electron flow between quinol oxidation Qo site of cytochrome bc1 and cytochrome c revealed by combinatory effects of mutations in cytochrome b, iron-sulfur protein and cytochrome c1 Bioch. Biophys. Acta 1859, 754-761

    3. Borek A, Ekiert R, Osyczka A. (2018) Advances in understanding mechanism and physiology of cytochromes bc. Book chapter in: Mechanisms of primary energy transduction in biology. Chemical biology no. 5. Edited by M. Wikström. Royal Society of Chemistry London pp. 192-214.

    4. Nizioł J, Makyła-Juzak K, Marzec MM, Ekiert R, Marzec M, Gondek E. (2017) Thermal stability of the solid DNA as novel optical material. Optical Materials 66: 344-350

    5. Borek, A., Ekiert, R., Osyczka, A. (2016) Molekularne efekty mutacji mitochondrialnych w genie kodującym cytochrom b kompleksu III i ich wpływ na poziom produkcji wolnych rodników Postępy Biochemii 62 (2) 162-172

    6.Sarewicz, M., Ekiert, R., Osyczka A. (2016) Book chapter: Inter-Monomer Electron Transfer in Cytochrome bc Complexes in: Cytochrome Complexes: Evolution, Structures, Energy Transduction, and Signaling Advances in Photosynthesis and Respiration vol. 41 (Springer)

    7. Ekiert, E., Borek, A., Kuleta, P., Czernek, J., Osyczka, A. (2016) Mitochondrial disease-related mutations at the cytochrome b-iron-sulfur protein (ISP) interface: Molecular effects on the large-scale motion of ISP and superoxide generation studied in Rhodobacter capsulatus cytochrome bc1. BBA Bioenergetics 1857: 1102-1110

    8. Nizioł J, Ekiert R, Śniechowski M, Słomiany M, Marzec M. (2016) Thermally forced transitions of DNA-CTMA complex microstructure. Optical Materials 56: 84-89

    9. Borek, A., Kuleta, P., Ekiert, R., Pietras, R., Sarewicz, M., Osyczka, A. (2015) Mitochondrial Disease-related Mutation G167P in Cytochrome b of Rhodobacter capsulatus Cytochrome bc1 (S151P in Human) Affects the Equilibrium Distribution of [2Fe-2S] Cluster and Generation of Superoxide. J Biol Chem 290, 23781-23792

    10. Ekiert, R., Czapla, M., Sarewicz, M., Osyczka, A. (2014) Hybrid fusions show that inner-monomer electron transfer robustly supports cytochrome bc1 function in vivo. Biochem Biophys Res Commun 451: 270–275

    11. Ebert, D.H., Gabel, H.W., Robinson, N.D., Kastan, N.R., Hu, L.S., Cohen, S., Navarro, A.J., Lyst, M.J., Ekiert, R., Bird, A.P., Greenberg, M.E. (2013) Activity-dependent phosphorylation of MeCP2 T308 regulates interaction with NCoR co-repressor complex. Nature 499: 341-345

    12. Lyst, M.J., Ekiert, R., Ebert, D.H., Merusi, C., Nowak, J., Selfridge, J., Guy, J., Kastan, N.R., Robinson, N.D., de Lima Alves, F., Rappsilber, J., Greenberg, M.E., Bird, A. (2013) Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. Nature Neuroscience 16: 898-902

    13. Lee, W.C., Hough, M.T., Liu, W., Ekiert, R., Lindström, N.O., Hohenstein, P., Davies, J.A. (2010) Dact2 is expressed in the developing ureteric bud/collecting duct system of the kidney and controls morphogenetic behavior of collecting duct cells. Am J Physiol Renal Physiol 299: F740-F751

    14. Ekiert, R., Dulak, J. (2008) Rola reduktazy biliwerdyny w komórkach w stresie oksydacyjnym. Acta Mygenica 1:52-60